Uncovering the Kidney’s Role in Detoxification
When we think about detoxification, the liver and gastrointestinal tract often steal the spotlight. While these organs do indeed play a key role in eliminating toxins, let’s not forget the kidneys, another important player in the detoxification process.
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Understanding the detoxifying role of the kidneys
The kidneys are the unsung heroes of the detoxification saga, tasked with filtering the countless end products of metabolism and facilitating the elimination of toxins. In particular, the kidneys help remove toxins that have gone through phase II liver detoxification or direct excretion, along with excess water-soluble nutrients such as B vitamins and vitamin C, all excreted in the urine. While stool serves as another major route of elimination, other bodily fluids such as sweat, tears, saliva, hair, nails, and milk contribute to detoxification to a lesser extent.
Internal functioning of the kidneys
To understand the detoxifying capabilities of the kidneys, let’s delve into their anatomy and function. These sophisticated bean-shaped organs boast a complex structure comprising a cortex (outer layer), pith (inner part), and central pelvis. The kidneys act as nature’s efficient filters and can clean the entire volume of blood in the body in less than an hour, underscoring their remarkable efficiency.
Blood enters the kidneys through the renal artery, passing through the cortex to reach the nephrons – the functional units responsible for filtering the blood. Inside the nephrons, the blood meets the glomeruli, bundles of blood vessels housed in Bowman’s capsules. As blood flows through the glomeruli, waste and excess water diffuse into Bowman’s capsules. Subsequently, the tubules beat off the excess and form urine, while the regenerable substances are reabsorbed into the bloodstream through the capillaries. The filtered blood then travels back to the heart via the renal vein, while the urine travels through the tubules to the central pelvis and finally leaves the body via the ureters to the bladder.
The basic structure of the kidneys from Study Read from Success
Elimination of toxic substances: duty of the kidneys
Toxic substances infiltrate our systems through three primary routes: inhalation through the respiratory tract, direct skin contact through the integumentary system, or ingestion through the gastrointestinal (GI) tract. While the pulmonary and GI tracts boast large areas for absorption, skin absorption, especially of fat-soluble compounds, presents permeability problems if not compromised. Once absorbed, toxic substances travel through the bloodstream and eventually meet the kidneys for elimination.
As the blood flows through the kidneys, large amounts of toxic substances, if not bound to plasma proteins and small enough, pass effortlessly through the glomeruli, with the ionized variants culminating in the urine, while the lipophilic counterparts may undergo reabsorption into the renal circulation. Notably, nephrotoxic mycotoxins such as ochratoxin A (OTA) show a propensity for renal reabsorption, thus perpetuating their deleterious effects. Other mycotoxins, including selected aflatoxins and T2 toxin, along with chemical toxicants such as mycophenolic acid (MPA), underscore the kidney’s vulnerability to toxic attack.
Supporting kidney health
With insight into the multifaceted detoxification role of the kidneys and their susceptibility to toxic substances, the question arises: how can we promote kidney health? While eliminating or reducing your toxic load reigns supreme, taking care of kidney health is equally paramount. Exploring ways to improve kidney function, whether through dietary intervention, hydration, or lifestyle modification, lays the foundation for optimal detoxification.
In the complex dance of detoxification, the kidneys stand as devoted guardians, persistently filtering toxins and protecting systemic health. As we continue to unravel the complexities of detoxification pathways, caring for kidney health becomes a cornerstone in the pursuit of holistic wellness.
References
1. Pizzorno J. The Kidney Dysfunction Epidemic, Part 1: Causes. Integr Med (Encinitas). 2015 Dec;14(6):8-13. PMID: 26807064; PMCID: PMC4718206.
2. Richards I and Bourgeois M. Principles and Practice of Toxicology in Public Health. 2014. ISBN: 9781449645267
3. A, Fardon J, Friend J, Temple N, Routh, K. et al. The Amazing Body. Smithsonian. 2017. First American Edition. Pg. 154-155. ISBN: 978-1-4654-6239-8
4. University of Michigan. Kidney Function. http://websites.umich.edu/~elements/web_mod/viper/kidney_function.htm
5. Khoury A and Atoui A. Ochratoxin A: General Overview and Actual Molecular Status. Toxins. 2010. 2(4): 461-493. PMID: 22069596
6. Gupta, Ramesh C. Veterinary Toxicology. Basic and Clinical Principles 3rd edition. 2018.
7. Plumlee KH. Mycotoxins Toxicokinetics. Clinical Veterinary Toxicology. 1st Edition. 2004
8. Abramson D. MYCOTOXINS Toxicology. Encyclopedia of Food Microbiology. 1999. Pages 1539-1547. ISBN 9780122270703. https://doi.org/10.1006/rwfm.1999.1150.
9. Mohan J, Sheik Abdul N, Nagiah S, Ghazi T, Chuturgoon AA. Fumonisin B2 Induces Mitochondrial Stress and Mitophagy in Human Embryonic Kidney (Hek293) Cells-A Preliminary Study. Toxins (Basel). 2022 Feb 25;14(3):171. doi: 10.3390/toxins14030171. PMID: 35324667; PMCID: PMC8954924.
10. Coppock RW, Dziwenka MM. Mycotoxins. Biomarkers in Toxicology. 2014. Pages 549-562.ISBN 9780124046306. https://doi.org/10.1016/B978-0-12-404630-6.00032-4. https://www.sciencedirect.com/science/article/pii/B9780124046306000324.
11. Nassar AY, Megalla SE, El-Fattah HM, Hafez AH, El-Deap TS. Binding of aflatoxin B1, G1 and M to plasma albumin. Mycopathologia. 1982 Jul 23;79(1):35-8. doi: 10.1007/BF00636179. PMID: 6811900.
12. Adhikari M, Negi B, Kaushik N, Adhikari A, Al-Khedhairy AA, Kaushik NK, Choi EH. T-2 mycotoxin: toxicological effects and decontamination strategies. Oncotarget. 2017 May 16;8(20):33933-33952. doi: 10.18632/oncotarget.15422. PMID: 28430618; PMCID: PMC5464924.
13. Gayathri, L., Akbarsha, M. & Ruckmani, K. In vitro study on aspects of molecular mechanisms underlying invasive aspergillosis caused by gliotoxin and fumagillin, alone and in combination. Sci Rep 10, 14473 (2020). https://doi.org/10.1038/s41598-020-71367-2
14. Amuzie CJ, Islam Z, Kim JK, Seo JH, Pestka JJ. Kinetics of satratoxin g tissue distribution and excretion following intranasal exposure in the mouse. Toxicol Sci. 2010;116(2):433-440. doi:10.1093/toxsci/kfq142
15. Amuzie CJ, Islam Z, Kim JK, Seo JH, Pestka JJ. Kinetics of satratoxin g tissue distribution and excretion following intranasal exposure in the mouse. Toxicol Sci. 2010;116(2):433-440. doi:10.1093/toxsci/kfq142
16. Food and Drug Association. Mycophenolic acid (Myfortic). https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050791s002lbl.pdf
17. Lamba V, Sangkuhl K, Sanghavi K, Fish A, Altman RB, and KE.PharmGKB. Mycophenolic Acid Pathway. Pharmacogenetics and genomics.2014. PMID:24220207. https://www.pharmgkb.org/pathway/PA165964832
18. Hooijmaaijer E, Brandl M, Nelson J, Lustig D. Degradation products of mycophenolate mofetil in aqueous solution. Drug Dev Ind Pharm. 1999 Mar;25(3):361-5. doi: 10.1081/ddc-100102183. PMID: 10071831.
19. Ye M, Lin W, Zheng J, Lin S. N-acetylcysteine for chronic kidney disease: a systematic review and meta-analysis. Am J Transl Res. 2021 Apr 15;13(4):2472-2485. PMID: 34017406; PMCID: PMC8129408.
20. Kolluru GK, Kevil CG. Beets, bacteria, and blood flow: a lesson of three Bs. Circulation. 2012 Oct 16;126(16):1939-40. doi: 10.1161/CIRCULATIONAHA.112.136515. Epub 2012 Sep 19. PMID: 22992323; PMCID: PMC4078643.
21. Nair AR, Masson GS, Ebenezer PJ, Del Piero F, Francis J. Role of TLR4 in lipopolysaccharide-induced acute kidney injury: protection by blueberry. Free Radic Biol Med. 2014 Jun;71:16-25. doi: 10.1016/j.freeradbiomed.2014.03.012. Epub 2014 Mar 19. PMID: 24657730.
22. Asiwe JN, Kolawole TA, Anachuna KK, Ebuwa EI, Nwogueze BC, Eruotor H, Igbokwe V. Cabbage juice protect against lead-induced liver and kidney damage in male Wistar rat. Biomarkers. 2022 Mar;27(2):151-158. doi: 10.1080/1354750X.2021.2022210. Epub 2022 Jan 3. PMID: 34974788.
23. Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013 Sep 17;1(1):448-56. doi: 10.1016/j.redox.2013.09.003. PMID: 24191240; PMCID: PMC3814973.
24. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003 Dec;26(12):3215-8. doi: 10.2337/diacare.26.12.3215. PMID: 14633804.
25. National Kidney Foundation. Use of Herbal Supplements in Chronic Kidney Disease. 2009. https://kidneyhi.org/use-of-herbal-supplements-in-chronic-kidney-disease/